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IBL-302

CAT: 0931-T86698-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T86698-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1414455-21-2
Target
PI3K, Akt, mTOR, Pim
Related Pathways
Cytoskeletal Signaling, Chromatin/Epigenetic, PI3K/Akt/mTOR signaling, JAK/STAT signaling
Bioactivity
IBL-302 (AMU302), an orally available dual-signaling inhibitor targeting PIM and PI3K/AKT/mTOR, is effective against breast cancer and neuroblastoma. It has shown in vivo efficacy in a nude mouse xenograft model by combating trastuzumab resistance. Additionally, IBL-302 augments the effectiveness of widely used cytotoxic chemotherapy drugs such as cisplatin, doxorubicin, and etoposide [1] [2] [3].
Smiles
CC=1C2=C3C(C=4SC(=CC4)CNC(=O)C=5C=C(S(=O)(=O)NC6=CC(C1S3)=CN=C6OC)C=CC5F)=NC=N2
Molecular Formula
C25H18FN5O4S3
Molecular Weight
567.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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