HSD17B13-IN-16

• Target:

  Dehydrogenase

• Related Pathways:

  Metabolism

• Bioactivity:

  HSD17B13-IN-16 (compound 8) serves as a potent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), demonstrating an IC50 of <0.1 ?M and <1 ?M when using estradiol and Leukotriene B3 as substrates, respectively. The compound is notably significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].

• Smiles:

  C(NCC1=C(OC)C=CC=C1)(=O)C2=C(NC(=O)C3=CC(Cl)=C(O)C=C3)C=CS2

• Molecular Formula:

  C20H17ClN2O4S

• Molecular Weight:

  416.88

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2758802-09-2