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GRL-190-21

CAT: 0931-T86525-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T86525-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2755957-14-1
Target
SARS-CoV
Related Pathways
Microbiology/Virology
Bioactivity
GRL-190-21 (compound 5e), an inhibitor of SARS-Cov-2-Mpro, shows potent antiviral activity, with a K_i of 0.04 nM and an EC_50 of 0.26 μM in VeroE6 cells. It significantly reduces the infectivity, replication, and cytopathic effect of SARS-CoV-2 without notable toxicity [1].
Smiles
C(N[C@@H](C[C@H]1C(=O)NCCC1)C#N)(=O)[C@@H]2[C@@]3([C@@](C3(C)C)(CN2C([C@@H](NC(C(F)(F)F)=O)[C@@](C)(C)C)=O)[H])[H]
Molecular Formula
C24H34F3N5O4
Molecular Weight
513.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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