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F44-A13

CAT: 0931-T86396-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T86396-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1338190-14-9
Target
PPAR, Cytochromes P450, FXR, Retinoid Receptor, ROR
Related Pathways
Metabolism, DNA Damage/DNA Repair
Bioactivity
F44-A13 is an orally active, highly selective farnesoid X receptor (FXR) antagonist with an IC50 value of 1.1 μM. It optimizes cholesterol metabolism and reduces activity by inducing CYP7A1 expression, lowering cholesterol, triglycerides, and low-density lipoprotein cholesterol (LDL-C) levels in mouse models. F44-A13 is applicable for studying metabolic diseases associated with lipid disorders [1].
Smiles
C(N(CC1CC1)C(NC(C)(C)C)=O)C2=C(OS(=O)(=O)C3=CC=C(NC(C)=O)C=C3)C=C(N(CC)CC)C=C2
Molecular Formula
C28H40N4O5S
Molecular Weight
544.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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