Products for Research Use Only
RegisterLogin

(S) -3'-hydroxy Blebbistatin

CAT: 0931-T85155-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T85155-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2097136-42-8
Target
Others, Myosin
Related Pathways
Cytoskeletal Signaling, Others
Bioactivity
(S) -3'-hydroxy-Blebbistatin is a more stable and less phototoxic derivative of (–) -blebbistatin, retaining the latter's properties as a selective, cell-permeable inhibitor of non-muscle myosin II ATPases. Unlike its predecessor, (S) -3'-hydroxy-Blebbistatin exhibits reduced fluorescence, improving its utility in live cell imaging applications by diminishing degradation into cytotoxic intermediates under blue light exposure (450-490 nm) . It effectively inhibits the Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB across various species with IC50 values ranging from 0.5-5 μM and shows minimal inhibition against smooth muscle myosin with an IC50 of 80 μM. This compound plays a critical role in preventing apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells, mirroring the active (–) -blebbistatin enantiomer in mechanism and efficacy.
Smiles
O[C@]12C(N(CC1)C3=CC(O)=CC=C3)=NC=4C(C2=O)=CC(C)=CC4
Molecular Formula
C18H16N2O3
Molecular Weight
308.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T85257-01(S) -3'-amino Blebbistatin
T36335-01(S) -nitro-Blebbistatin
T6038-01(-) -Blebbistatin
T12503-01(+) -Blebbistatin
T21550-01Blebbistatin
T12791-01(S) -3-Hydroxy Midostaurin
T36400-01Para-amino-Blebbistatin
T35458-01(R) -nitro-Blebbistatin
TYD-02390-01(S) -3-Hydroxy-13-methyltetradecanoyl-CoA
TYD-02259-01(S) -3-Hydroxy-11Z-octadecenoyl-CoA

Alternative Products

CatalogName
HY-129452-01(S) -3'-Hydroxy blebbistatin
GTR19232180-01(S) -3'-amino Blebbistatin
B2105(+/-) -Blebbistatin ((+/-) -1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one)
B2105-01AS- (-) -Blebbistatin ((-) -1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one)
MBS6047937-01(S) - (-) -Blebbistatin ((-) -1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one)
B2105-01(R) - (+) -Blebbistatin ((+) -1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one)
B1387-S(-)-Blebbistatin
B6847-1(±)-Blebbistatin
366870-01(-) -Blebbistatin
2407-5(+)-Blebbistatin

Popular Products