(S) -3'-hydroxy Blebbistatin

CAT: 0931-T85155-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T85155-01Size:10 mg
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CAS Number
2097136-42-8
Target
Others|||Myosin
Related Pathways
Cytoskeletal Signaling|||Others
Bioactivity
(S) -3'-hydroxy-Blebbistatin is a more stable and less phototoxic derivative of (–) -blebbistatin, retaining the latter's properties as a selective, cell-permeable inhibitor of non-muscle myosin II ATPases. Unlike its predecessor, (S) -3'-hydroxy-Blebbistatin exhibits reduced fluorescence, improving its utility in live cell imaging applications by diminishing degradation into cytotoxic intermediates under blue light exposure (450-490 nm) . It effectively inhibits the Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB across various species with IC50 values ranging from 0.5-5 µM and shows minimal inhibition against smooth muscle myosin with an IC50 of 80 µM. This compound plays a critical role in preventing apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells, mirroring the active (–) -blebbistatin enantiomer in mechanism and efficacy.
Smiles
O[C@]12C(N(CC1)C3=CC(O)=CC=C3)=NC=4C(C2=O)=CC(C)=CC4
Molecular Formula
C18H16N2O3
Molecular Weight
308.33
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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Alternative Products

CatalogName
HY-129452-01(S) -3'-Hydroxy blebbistatin
B2105(+/-) -Blebbistatin ((+/-) -1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one)
MBS6047937-01(S) - (-) -Blebbistatin ((-) -1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one)
B2105-01AS- (-) -Blebbistatin ((-) -1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one)
MBS6047622-01(R) - (+) -Blebbistatin ((+) -1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one)
262824-01(+/-) -Blebbistatin
BUP05856-01(-) -Blebbistatin
sc-203532(±) -Blebbistatin
2407-1(+)-Blebbistatin
B6847-10(±)-Blebbistatin

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