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20-ethyl Prostaglandin E2

CAT: 0931-T84651-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T84651-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
37492-24-3
Target
Prostaglandin Receptor, Others
Related Pathways
Immunology/Inflammation, Others, GPCR/G Protein
Bioactivity
20-Ethyl Prostaglandin E2 (20-ethyl PGE2) is an analog of Prostaglandin E2 (PGE2) characterized by an extended ω-chain due to two additional methylene carbon atoms. Compared to unoprostone, a clinically approved glaucoma medication and the only extensively studied prostaglandin analog sharing this structural modification, 20-ethyl PGE2 maintains the natural 15 (S) allylic hydroxyl in its lower side chain, potentially enhancing its effectiveness. Unoprostone, despite being an F-series prostaglandin, exhibits reduced affinity for FP receptors because of its lower side chain modifications (13,14-dihydro-15-keto), which diminishes its medicinal potency. Notably, 20-ethyl PGE2's efficacy relative to unoprostone and its interaction with EP or other prostanoid receptors remains unconfirmed due to the lack of published ligand binding assays. E-type prostaglandins, including 20-ethyl PGE2, are broadly acknowledged for their inflammatory, cytoprotective, and diverse biological activities.
Smiles
C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](CCCCCCC)O)[C@H](O)CC1=O
Molecular Formula
C22H36O5
Molecular Weight
380.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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