(Z) -RG-13022

• Target:

  Others|||EGFR

• Related Pathways:

  Others|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis

• Bioactivity:

  (Z) -RG-13022 is a tyrosine kinase (TK) inhibitor that preferentially inhibits the TK activity of the EGF receptor, restricting the EGF-stimulated growth of cultured cells. It demonstrates an IC50 of 11 ?M for DNA synthesis in HN5 cells, showcasing thrice the potency of its isomer, (E) -RG-13022 (IC50 = 38 ?M) . This compound is applied in breast cancer cell research [1] [2].

• Smiles:

  C(=C(\C#N)/C=1C=CC=NC1)\C2=CC(OC)=C(OC)C=C2

• Molecular Formula:

  C16H14N2O2

• Molecular Weight:

  266.29

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  149286-90-8