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CPTH6 hydrobromide

CAT: 0931-T84391-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T84391-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2321332-57-2
Target
Others, Apoptosis
Related Pathways
Apoptosis, Others
Bioactivity
CPTH6, a thiazole derivative, selectively inhibits the lysine acetyltransferase activity of Gcn5 and pCAF without affecting p300 or CBP. It effectively blocks the acetylation of H3/H4 histones and α-tubulin in various leukemia cell lines, leading to reduced cell viability by arresting the cell cycle in the G0/G1 phase and inducing apoptosis. Additionally, CPTH6 disrupts autophagy across several tumor cell lines, primarily by interfering with ATG7-mediated autophagosomal membrane elongation.
Smiles
N(N=C1CC(C)CC1)C2=NC(=CS2)C3=CC=C(Cl)C=C3.Br
Molecular Formula
C15H16ClN3S?HBr
Molecular Weight
386.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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