CPTH6 hydrobromide

• Target:

  Others|||Apoptosis

• Related Pathways:

  Apoptosis|||Others

• Bioactivity:

  CPTH6, a thiazole derivative, selectively inhibits the lysine acetyltransferase activity of Gcn5 and pCAF without affecting p300 or CBP. It effectively blocks the acetylation of H3/H4 histones and ?-tubulin in various leukemia cell lines, leading to reduced cell viability by arresting the cell cycle in the G0/G1 phase and inducing apoptosis. Additionally, CPTH6 disrupts autophagy across several tumor cell lines, primarily by interfering with ATG7-mediated autophagosomal membrane elongation.

• Smiles:

  N(N=C1CC(C)CC1)C2=NC(=CS2)C3=CC=C(Cl)C=C3.Br

• Molecular Formula:

  C15H16ClN3S?HBr

• Molecular Weight:

  386.7

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2321332-57-2