CST 530

• Target:

  Ligand for E3 Ligase|||Apoptosis|||IAP

• Related Pathways:

  PROTAC|||Apoptosis

• Bioactivity:

  CST 530 is a monovalent IAP antagonist. It induces cIAP1 and cIAP2 autodegradation in MM.1S cells (cIAP1 degradation at 0.1 ?M and cIAP2 degradation at 1 ?M after 16 hours) . CST 530 reduces cell viability in multiple cancer cell lines including SUDHL6, MOLM13, and HEL (IC50 values ??of 170 nM, 420 nM, and 450 nM, respectively) .

• Smiles:

  C([C@@H](NC([C@@H](NC)C)=O)C1CCCCC1)(=O)N2[C@H](C(N[C@H]3C=4C(CCC3)=CC=CC4)=O)C[C@H](OC5=CC=CC=C5)C2

• Molecular Formula:

  C33H44N4O4

• Molecular Weight:

  560.727

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  847137-53-5