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2- (cyclohexylmethyl) -Plumbagin

CAT: 0931-T83877-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T83877-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others
Related Pathways
Others
Bioactivity
2- (Cyclohexylmethyl) -Plumbagin, a naphthoquinone derivative, exhibits selective cytotoxicity towards PANC-1 human pancreatic cancer cells under nutrient-deprived conditions—a situation akin to the pancreatic cancer tumor microenvironment—over those in nutrient-rich settings, with PC50 values of 0.11 and 47.2 μM, respectively. At a 1 μM concentration, it triggers apoptosis in PANC-1 cells. Furthermore, this compound specifically inhibits the phosphorylation of Akt and mammalian target of rapamycin (mTOR) in PANC-1 cells under nutrient scarcity. In a MiaPaCa-2 pancreatic cancer mouse xenograft model, it significantly reduces tumor volume and weight when administered at 50 and 250 μg/animal dosages five times weekly.
Smiles
OC1=C2C(C(C(CC3CCCCC3)=CC2=O)=O)=CC=C1
Molecular Formula
C17H18O3
Molecular Weight
270.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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HY-169830-012- (Cyclohexylmethyl) -plumbagin
A4456-5.1Plumbagin

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