BMS-986172

• Target:

  Acyltransferase

• Related Pathways:

  Metabolism

• Bioactivity:

  BMS-986172 is an orally active, highly selective inhibitor of MGAT2, with inhibitory concentrations (IC50) of 4.6 nM for human MGAT2 (hMGAT2) and 20 nM for mouse MGAT2 (mMGAT2) . It exhibits an in vitro half-life (T1/2) greater than 120 minutes and is known to decrease food intake and body weight. This compound is promising for research in metabolic disorders, including obesity and non-alcoholic steatohepatitis (NASH) [1].

• Smiles:

  [C@] (F) (F) (F) [C@]1 (CC (=C (C (=O) N1) N2N=NNC2=O) C3=NN (CC4CC4) C=C3) C5=C (F) C=C (OCCCC (F) (F) F) C=C5

• Molecular Formula:

  C24H22F7N7O3

• Molecular Weight:

  589.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1808258-99-2