BMS-986172

• Target:

  Acyltransferase

• Related Pathways:

  Metabolism

• Bioactivity:

  BMS-986172 is an orally active, highly selective inhibitor of MGAT2, with inhibitory concentrations (IC50) of 4.6 nM for human MGAT2 (hMGAT2) and 20 nM for mouse MGAT2 (mMGAT2) . It exhibits an in vitro half-life (T1/2) greater than 120 minutes and is known to decrease food intake and body weight. This compound is promising for research in metabolic disorders, including obesity and non-alcoholic steatohepatitis (NASH) [1].

• Smiles:

  [C@](F)(F)(F)[C@]1(CC(=C(C(=O)N1)N2N=NNC2=O)C3=NN(CC4CC4)C=C3)C5=C(F)C=C(OCCCC(F)(F)F)C=C5

• Molecular Formula:

  C24H22F7N7O3

• Molecular Weight:

  589.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1808258-99-2