BMS-986172

CAT: 0931-T82848-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T82848-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1808258-99-2
Target
Acyltransferase
Related Pathways
Metabolism
Bioactivity
BMS-986172 is an orally active, highly selective inhibitor of MGAT2, with inhibitory concentrations (IC50) of 4.6 nM for human MGAT2 (hMGAT2) and 20 nM for mouse MGAT2 (mMGAT2) . It exhibits an in vitro half-life (T1/2) greater than 120 minutes and is known to decrease food intake and body weight. This compound is promising for research in metabolic disorders, including obesity and non-alcoholic steatohepatitis (NASH) [1].
Smiles
[C@](F)(F)(F)[C@]1(CC(=C(C(=O)N1)N2N=NNC2=O)C3=NN(CC4CC4)C=C3)C5=C(F)C=C(OCCCC(F)(F)F)C=C5
Molecular Formula
C24H22F7N7O3
Molecular Weight
589.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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