SR-1114

• Target :

  PROTACs

• Related Pathways :

  PROTAC

• Bioactivity :

  SR-1114, a first-in-class PROTAC ENL degrader, induces rapid CRBN-dependent ENL degradation with DC50 values of 150 nM in MV4;11 cells, 311 nM in MOLM-13 cells, and 1.65 ?M in OCI/AML-2 cells [1].

• Smiles :

  O=C(NC1CCC1)C=2C=CC3=NC(=CN3C2)C=4C=CC=C(C4)NS(=O)(=O)NCCOCCOCCNC(=O)COC5=CC=CC=6C(=O)N(C(=O)C56)C7C(=O)NC(=O)CC7

• Molecular Formula :

  C39H42N8O11S

• Molecular Weight :

  830.86

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2769141-82-2