α-Conotoxin GID

CAT: 0931-MF-0157738-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0157738-01Size:5 mg
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CAS Number
547741-78-6
Target
AChR
Related Pathways
Neuroscience
Bioactivity
?-Conotoxin GID is a paralytic peptide neurotoxin that selectively antagonizes nAChR with IC50 values of 5 nM (?7), 3 nM (?3?2), and 150 nM (?4?2) . This small, disulfide-rich peptide has potential for chronic pain inhibition. The presence of a C-terminal carboxylate is crucial, as substitution with a C-terminal carboxamide results in loss of activity against ?4?2 nAChR. Derived from species of the genus Conus [1] [2] [3].
Smiles
O=C1[C@]2(N(C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@]3(NC(=O)[C@H](C)NC(=O)[C@]4(N(C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@](CSSC[C@@H](C(O)=O)NC(=O)[C@H]([C@@H](C)C)NC(=O)[C@H](CC5=CN=CN5)N1)(NC(=O)[C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)N)=O)CCCNC(=N)N)=O)CC(O)=O)=O)CC(C(O)=O)C(O)=O)=O)CSSC3)[H])CCC4)[H])[H])C[C@H](O)C2)[H]
Molecular Formula
C84H132N30O31S4
Molecular Weight
2186.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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