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SMD-3040 intermediate-2

CAT: 0804-HY-400685-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-400685-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SMD-3040 intermediate-2 is an intermediate in the synthesis of SMD-3040. SMD-3040 contains SMARCA2/4 ligands, linker and VHL ligands and is a selective SMARCA2 degrader. MD-3040 can be used for ADC drug synthesis and has strong tumor growth inhibition in tumor xenograft models[1].
CAS Number
2632308-00-8
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
Drug Intermediate
Type
ADC Related
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smd-3040-intermediate-2.html
Purity
95.82
Solubility
10 mM in DMSO
Smiles
N#CC1=CC=C(N2CC3(CC2C)CCN(CC3)C(OC(C)(C)C)=O)C=C1Cl
Molecular Formula
C21H28ClN3O2
Molecular Weight
389.92
Precautions
H302, H315, H319, H335
References & Citations
[1]Yang L, et.al. Discovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity. J Med Chem. 2023 Jul 31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported

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