DHFR-IN-8

• Target:

  Others|||DHFR|||Antibacterial

• Related Pathways:

  Metabolism|||Microbiology/Virology|||Cell Cycle/Checkpoint|||Others|||DNA Damage/DNA Repair

• Bioactivity:

  DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth. This compound effectively suppresses methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 with an IC50 of 15.6 ng/mL in mouse models of systemic and thigh infections [1].

• Molecular Formula:

  C18H14N6S

• Molecular Weight:

  346.41

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C