MLKL-IN-6

• Target:

  Necroptosis|||MLK

• Related Pathways:

  Apoptosis|||MAPK

• Bioactivity:

  MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are critical steps in cell necrosis. Additionally, MLKL-IN-6 restrains immune cell death, diminishes adhesion factor expression, exhibits low cytotoxicity, impedes hepatic stellate cell activation, decreases liver fibrosis marker levels, and exerts anti-fibrotic effects [1].

• Smiles:

  OC1=CC (C#CCN2C (N=C (/C=C/C (OC) =O) N3C) =C3C (N (C) C2=O) =O) =CC=C1

• Molecular Formula:

  C20H18N4O5

• Molecular Weight:

  394.38

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C