MLKL-IN-6

• Target :

  Necroptosis|||MLK

• Related Pathways :

  Apoptosis|||MAPK

• Bioactivity :

  MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are critical steps in cell necrosis. Additionally, MLKL-IN-6 restrains immune cell death, diminishes adhesion factor expression, exhibits low cytotoxicity, impedes hepatic stellate cell activation, decreases liver fibrosis marker levels, and exerts anti-fibrotic effects [1].

• Smiles :

  OC1=CC(C#CCN2C(N=C(/C=C/C(OC)=O)N3C)=C3C(N(C)C2=O)=O)=CC=C1

• Molecular Formula :

  C20H18N4O5

• Molecular Weight :

  394.38

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C