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MHTT-IN-2

CAT: 0931-T79717Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79717Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2743336-70-9
Target
Huntingtin
Related Pathways
Neuroscience
Bioactivity
MHTT-IN-2 (compound 27) is a potent inhibitor of mutant huntingtin protein (mHTT) with an EC50 value of 0.066 μM. It specifically modulates the splicing of HTT RNA exons [49-50], serving as a splicing regulator for the HTT gene. Demonstrating inhibitory effects in vitro and in vivo, mHTT-IN-2 has been tested in human HD stem cells and mouse BACHD models. Additionally, it is applicable in the investigation of branaplam-related peripheral neuropathy [1].
Smiles
FC=1C=2N(C=C(NC(=O)C=3C=NC(=CN3)N4C[C@H](NC5CC5)CC4)C1)C=C(C)N2
Molecular Formula
C20H22FN7O
Molecular Weight
395.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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