PI3Kα-IN-13

CAT: 0931-T79685-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T79685-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2955529-67-4

Target

PI3K

Related Pathways

PI3K/Akt/mTOR signaling

Bioactivity

PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines, exhibiting IC50 values of 0.75 μM (MCF-7), 3.79 μM (HCT-116), 13.71 μM (MDA-MB-231), and 9.85 μM (SW620) . This compound also impedes tumor cell colony formation, migration, and invasion [1].

Smiles

NC1=NC2=CC(C3=CC=4N=C(N5C[C@@]6([C@](C5)(OCCO6)[H])[H])C=NC4C=C3)=CC=C2O1

Molecular Formula

C21H19N5O3

Molecular Weight

389.41

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GTR19218973-01	PI3Kα-IN-13
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PI3Kα-IN-13

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