PI3K?-IN-13

• Target :

  PI3K

• Related Pathways :

  PI3K/Akt/mTOR signaling

• Bioactivity :

  PI3K?-IN-13 (Compound 18a), a PI3K? inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines, exhibiting IC50 values of 0.75 ?M (MCF-7), 3.79 ?M (HCT-116), 13.71 ?M (MDA-MB-231), and 9.85 ?M (SW620) . This compound also impedes tumor cell colony formation, migration, and invasion [1].

• Smiles :

  NC1=NC2=CC(C3=CC=4N=C(N5C[C@@]6([C@](C5)(OCCO6)[H])[H])C=NC4C=C3)=CC=C2O1

• Molecular Formula :

  C21H19N5O3

• Molecular Weight :

  389.41

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2955529-67-4