LYP-IN-4

• Target:

  Phosphatase

• Related Pathways:

  Metabolism

• Bioactivity:

  LYP-IN-4 (compound D14), a reversible and selective lymphotyrosine phosphatase (LYP) inhibitor (Ki=1.34 ?M, IC50=3.52?M), regulates TCR signaling, increases PD-1/PD-L1 expression, and strengthens anti-tumor immunity. It also stimulates T cell activation, impedes M2 macrophage polarization, and suppresses tumor progression in MC38 isogenic mouse models.

• Molecular Formula:

  C29H21ClN2O8S

• Molecular Weight:

  593

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C