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SPC-180002

CAT: 0931-T79601-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T79601-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2170274-53-8
Target
Reactive Oxygen Species|||Sirtuin|||Nrf2
Related Pathways
DNA Damage/DNA Repair|||Chromatin/Epigenetic|||NF-?B|||Immunology/Inflammation|||Metabolism
Bioactivity
SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 ?M for SIRT1 and SIRT3, respectively. It disrupts redox homeostasis through ROS generation, consequently enhancing p21 protein stability and inducing mitochondrial dysfunction. Furthermore, this compound significantly impedes cell cycle progression and malignancy proliferation, while also activating the Nrf2 signaling pathway [1].
Smiles
N(CC(C(OC)=O)=C)(CC(C(OC)=O)=C)CCC1=CC=CC=C1
Molecular Formula
C18H23NO4
Molecular Weight
317.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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