TRAP1-IN-2

• CAS Number :

  3031102-92-5

• Target :

  HSP

• Related Pathways :

  Cytoskeletal Signaling|||Metabolism

• Bioactivity :

  TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients. It inhibits oxidative phosphorylation (OXPHOS) and shifts cellular metabolism toward glycolysis. Additionally, TRAP1-IN-2 compromises the stability of the TRAP1 tetramer and disrupts the mitochondrial membrane potential [1].

• Smiles :

  O=C(N1CC2=C(C1)C(OC)=CC=C2)C3=CC=C(C(C(N4CC5=CC=C(C=C5C4)OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)=O)=C3)O.F[P-](F)(F)(F)(F)F

• Molecular Formula :

  C46H42F6N2O5P2

• Molecular Weight :

  878.77

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C