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TRAP1-IN-2

CAT: 0931-T79286-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79286-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3031102-92-5
Target
HSP
Related Pathways
Cytoskeletal Signaling, Metabolism
Bioactivity
TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients. It inhibits oxidative phosphorylation (OXPHOS) and shifts cellular metabolism toward glycolysis. Additionally, TRAP1-IN-2 compromises the stability of the TRAP1 tetramer and disrupts the mitochondrial membrane potential [1].
Smiles
O=C(N1CC2=C(C1)C(OC)=CC=C2)C3=CC=C(C(C(N4CC5=CC=C(C=C5C4)OCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8)=O)=C3)O.F[P-](F)(F)(F)(F)F
Molecular Formula
C46H42F6N2O5P2
Molecular Weight
878.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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