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BVFP

CAT: 0931-T79105-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T79105-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
357158-20-4
Target
Neurotensin Receptor
Related Pathways
GPCR/G Protein
Purity
0.9874
Bioactivity
BVFP is a PGRN-SORT1 inhibitor/SORT1 antagonist that binds to key residues 588-593 of PGRN, a multifunctional secreted glycoprotein, and SORT1, a neuronal receptor for PGRN.BVFP is able to block PGRN-SORT1 binding, restore extracellular levels of PGRN , inhibits SORT1-mediated rPGRN endocytosis, and has therapeutic potential for frontotemporal lobe dementia (FTLD-TDP) .
Smiles
O=C1N=C(C=CC=2C=CC=C(Br)C2)C=C(N1)C(F)(F)F
Molecular Formula
C13H8BrF3N2O
Molecular Weight
345.12
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

4-[(E)-2-(3-bromophenyl)ethenyl]-6-(trifluoromethyl)-1H-pyrimidin-2-one
CAS Number357158-20-4
PubChem CID5742099
IUPAC Name4-[(E)-2-(3-bromophenyl)ethenyl]-6-(trifluoromethyl)-1H-pyrimidin-2-one
Molecular FormulaC13H8BrF3N2O
Molecular Weight345.11
XLogP3.3
Topological Polar Surface Area41.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity482
SMILES
C1=CC(=CC(=C1)Br)/C=C/C2=NC(=O)NC(=C2)C(F)(F)F
InChI
InChI=1S/C13H8BrF3N2O/c14-9-3-1-2-8(6-9)4-5-10-7-11(13(15,16)17)19-12(20)18-10/h1-7H,(H,18,19,20)/b5-4+
InChIKey
DMNBJHFWSKYYJK-SNAWJCMRSA-N
Chemical Structure
2D Structure
2D structure of 4-[(E)-2-(3-bromophenyl)ethenyl]-6-(trifluoromethyl)-1H-pyrimidin-2-one
CAS: 357158-20-4
CID: 5742099
Formula: C13H8BrF3N2O
MW: 345.11
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight345.11
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass343.97721
Monoisotopic Mass343.97721
Topological Polar Surface Area41.5 Ų
Heavy Atom Count20
Formal Charge0
Complexity482
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5820766BVFP

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