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BVFP

CAT: 0804-HY-153686-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-153686-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BVFP binds to the PGRN588–593 peptide with a Kd of 20 μM. BVFP can disrupt PGRN-SORT1 binding. BVFP also inhibits SORT1-mediated rPGRN endocytosis[1].
CAS Number
357158-20-4
UNSPSC
12352005
Target
Neurotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bvfp.html
Concentration
10mM
Purity
98.12
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1N=C(C=C(C(F)(F)F)N1)/C=C/C2=CC(Br)=CC=C2
Molecular Formula
C13H8BrF3N2O
Molecular Weight
345.11
References & Citations
[1]Lee WC, et al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Hum Mol Genet. 2014 Mar 15;23 (6) :1467-78.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

4-[(E)-2-(3-bromophenyl)ethenyl]-6-(trifluoromethyl)-1H-pyrimidin-2-one
CAS Number357158-20-4
PubChem CID5742099
IUPAC Name4-[(E)-2-(3-bromophenyl)ethenyl]-6-(trifluoromethyl)-1H-pyrimidin-2-one
Molecular FormulaC13H8BrF3N2O
Molecular Weight345.11
XLogP3.3
Topological Polar Surface Area41.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity482
SMILES
C1=CC(=CC(=C1)Br)/C=C/C2=NC(=O)NC(=C2)C(F)(F)F
InChI
InChI=1S/C13H8BrF3N2O/c14-9-3-1-2-8(6-9)4-5-10-7-11(13(15,16)17)19-12(20)18-10/h1-7H,(H,18,19,20)/b5-4+
InChIKey
DMNBJHFWSKYYJK-SNAWJCMRSA-N
Chemical Structure
2D Structure
2D structure of 4-[(E)-2-(3-bromophenyl)ethenyl]-6-(trifluoromethyl)-1H-pyrimidin-2-one
CAS: 357158-20-4
CID: 5742099
Formula: C13H8BrF3N2O
MW: 345.11
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight345.11
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass343.97721
Monoisotopic Mass343.97721
Topological Polar Surface Area41.5 Ų
Heavy Atom Count20
Formal Charge0
Complexity482
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5820766BVFP

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