BACE1-IN-13

• Target:

  Beta-Secretase

• Related Pathways:

  Neuroscience

• Bioactivity:

  BACE1-IN-13 (Compound 36), an orally active inhibitor of BACE1, exhibits high potency with an IC50 of 2.9 nM and demonstrates greater efficacy in hA?42 cells (IC50 = 1.3 nM) . It is considered safe for the cardiovascular system and induces a sustained reduction of A?42 in both mouse and dog animal models [1].

• Smiles:

  C[C@]1(CN2C(C(N)=N1)=CC(C#N)=N2)C3=CC(NC(=O)C=4C=NC(OC)=CN4)=CC=C3F

• Molecular Formula:

  C20H17FN8O2

• Molecular Weight:

  420.4

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1397683-26-9