BACE1-IN-13

CAT: 0931-T79022-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T79022-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1397683-26-9

Target

Beta-Secretase

Related Pathways

Neuroscience

Bioactivity

BACE1-IN-13 (Compound 36), an orally active inhibitor of BACE1, exhibits high potency with an IC50 of 2.9 nM and demonstrates greater efficacy in hAβ42 cells (IC50 = 1.3 nM) . It is considered safe for the cardiovascular system and induces a sustained reduction of Aβ42 in both mouse and dog animal models [1].

Smiles

C[C@]1(CN2C(C(N)=N1)=CC(C#N)=N2)C3=CC(NC(=O)C=4C=NC(OC)=CN4)=CC=C3F

Molecular Formula

C20H17FN8O2

Molecular Weight

420.4

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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