ATR-IN-23

CAT: 0931-T78959-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T78959-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2923800-62-6

Target

ATM/ATR

Related Pathways

DNA Damage/DNA Repair, PI3K/Akt/mTOR signaling

Bioactivity

ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility in researching DNA damage response (DDR) -deficient cancers [1].

Smiles

N(C)C=1N(C2=NC(=C3C(=N2)C(S(C)(=O)=O)=CS3)N4[C@H](C)COCC4)C=5C(N1)=CC=CC5

Molecular Formula

C20H22N6O3S2

Molecular Weight

458.56

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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