PARP-1/2-IN-2

CAT: 0931-T78787-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T78787-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Apoptosis, PARP, CDK

Related Pathways

Apoptosis, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Chromatin/Epigenetic

Bioactivity

PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair and inducing cell cycle arrest and apoptosis. This compound also hampers the proliferation of TNBC cells and the growth of TNBC xenograft tumors [1].

Molecular Formula

C25H23IN8O3

Molecular Weight

610.41

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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PARP-1/2-IN-2

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