RIPK3-IN-3

• Target:

  Others|||MLK|||RIP kinase

• Related Pathways:

  Apoptosis|||NF-?B|||Others|||MAPK

• Bioactivity:

  RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor with a potent IC50 value of 10 nM, effectively blocking RIPK3-mediated phosphorylation of MLKL, preventing oligomerization and necroptosis induction. Moreover, RIPK3-IN-3 suppresses CXCL5 secretion and impedes AsPC-1 cell migration and invasion [1].

• Molecular Formula:

  C16H11N5S

• Molecular Weight:

  305.36

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C