RIPK3-IN-5

• Target:

  RIP kinase|||Necroptosis

• Related Pathways:

  Apoptosis|||NF-?B

• Bioactivity:

  RIPK3-IN-5 (compound 32) is a potent RIPK3 inhibitor with an IC50 of 27 nM. Additionally, it inhibits necroptosis with an EC50 of 0.45 ?M.

• Smiles:

  FC(C=CC=C1F)=C1NC2=NC=NC3=CC(C4=CN=C(N5CCN(C)CC5)C=C4)=CC=C32

• Molecular Formula:

  C24H22F2N6

• Molecular Weight:

  432.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C