RET-IN-22

• Target:

  C-RET|||Others

• Related Pathways:

  Others|||Apoptosis|||Tyrosine Kinase/Adaptors

• Bioactivity:

  RET-IN-22 (compound 17b) is a potent, selective, and orally active inhibitor of RET, exhibiting IC50 values of 20.9 nM for wild-type RET and 18.3 nM for RET-V804M. It demonstrates a highly selective inhibition profile across a broad spectrum of kinases, with notable specificity over EGFR and VEGFR2, and is implicated in exerting anticancer effects [1].

• Smiles:

  N (C (NC=1C=C (C (C (F) (F) F) (C) C) ON1) =O) C2=CC=C (C=3C=C (NN3) C4=CC=C (OCCN5CCOCC5) C=C4) C=C2

• Molecular Formula:

  C29H31F3N6O4

• Molecular Weight:

  584.59

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2918281-79-3