RET-IN-22

CAT: 0931-T78683-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T78683-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2918281-79-3

Target

C-RET, Others

Related Pathways

Others, Apoptosis, Tyrosine Kinase/Adaptors

Bioactivity

RET-IN-22 (compound 17b) is a potent, selective, and orally active inhibitor of RET, exhibiting IC50 values of 20.9 nM for wild-type RET and 18.3 nM for RET-V804M. It demonstrates a highly selective inhibition profile across a broad spectrum of kinases, with notable specificity over EGFR and VEGFR2, and is implicated in exerting anticancer effects [1].

Smiles

N(C(NC=1C=C(C(C(F)(F)F)(C)C)ON1)=O)C2=CC=C(C=3C=C(NN3)C4=CC=C(OCCN5CCOCC5)C=C4)C=C2

Molecular Formula

C29H31F3N6O4

Molecular Weight

584.59

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-149099	RET-IN-22
R1701-17	RET protein (RET)
V8277-100UG	RET Antibody / c-RET
V8276-100UG	C-RET Antibody / RET
030598	RET (ret proto-oncogene)
332425-01	Ret

RET-IN-22

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