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RET-IN-14

CAT: 0931-T63468-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T63468-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2755843-62-8
Target
C-RET, BTK, Others
Related Pathways
Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis, Others
Bioactivity
RET-IN-14 is a potent inhibitor of RET, capable of acting on RET (WT) (IC50 < 0.51 nM), RET (G810R) (IC50: 9.3 nM), RET (V804M) (IC50: 1.3 nM), BTK (C481S) (IC50: 9.2 nM) and BTK (C481S) (IC50 : 15 nM) . RET-IN-14 exhibits potential for tumor studies.
Smiles
NC=1N2C3=C(C=N2)C(=O)NC[C@H](C)OC=4C(CN=C(N3)C1C5=CC=C(NC(OC)=O)C=C5)=CC(F)=CN4
Molecular Formula
C24H23FN8O4
Molecular Weight
506.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C