I-287

CAT: 0931-T78672-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T78672-01Size:5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2014368-93-3
Target
Others|||ERK|||Protease-activated Receptor
Related Pathways
MAPK|||Others|||GPCR/G Protein
Bioactivity
I-287 is a selective, orally active PAR2 inhibitor that functions as a negative allosteric modulator of G?q and G?12/13 activity and their downstream effectors. It has been shown to attenuate Complete Freund's adjuvant-induced inflammation in mice, suggesting its utility in inflammation/immunology research [1].
Smiles
C(C)(C)(C)C1=C2C(=NC(=C1)C3=CC(F)=C(Cl)C=C3)C=C(C(=O)N4C(C)(C)CN(CC4)C5=CC=C(C(O)=O)C=N5)O2
Molecular Formula
C30H30ClFN4O4
Molecular Weight
565.04
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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