I-287

• Target:

  Others|||ERK|||Protease-activated Receptor

• Related Pathways:

  MAPK|||Others|||GPCR/G Protein

• Bioactivity:

  I-287 is a selective, orally active PAR2 inhibitor that functions as a negative allosteric modulator of G?q and G?12/13 activity and their downstream effectors. It has been shown to attenuate Complete Freund's adjuvant-induced inflammation in mice, suggesting its utility in inflammation/immunology research [1].

• Smiles:

  C(C)(C)(C)C1=C2C(=NC(=C1)C3=CC(F)=C(Cl)C=C3)C=C(C(=O)N4C(C)(C)CN(CC4)C5=CC=C(C(O)=O)C=N5)O2

• Molecular Formula:

  C30H30ClFN4O4

• Molecular Weight:

  565.04

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2014368-93-3