TPI-287

• Target:

  Others|||Microtubule Associated

• Related Pathways:

  Cytoskeletal Signaling|||Others

• Bioactivity:

  TPI 287 is a synthetic, third generation taxane with potential antineoplastic activity. TPI 287 binds to tubulin and stabilizes microtubules, resulting in inhibition of microtubule assembly/disassembly dynamics, cell cycle arrest at the G2/M phase, and apoptosis.

• Smiles:

  O (C (C) =O) [C@]12[C@@]3 ([C@]4 (C) [C@] ([C@@H] (OC (C) =O) C=5C (C) (C) [C@] (O) ([C@H]3OC (=O) C6=CC=CC=C6) C[C@H] (OC ([C@@H] ([C@@H] (NC (OC (C) (C) C) =O) CC (C) C) O) =O) C5C) (OC (C=C) O[C@]4 (C[C@]1 (OC2) [H]) [H]) [H]) [H]

• Molecular Formula:

  C46H63NO15

• Molecular Weight:

  869.99

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  849213-15-6