Phenyl sulfate

CAT: 0931-T77988Size: 5 mgDry Ice: NoHazardous: No
CAT#: T77988Size: 5 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
937-34-8
Target
Others|||Endogenous Metabolite
Related Pathways
Metabolism|||Others
Bioactivity
Phenyl sulfate is a gut microbiota-derived metabolite of tyrosine and a recognized uremic toxin. At a concentration of 30 µM, phenyl sulfate reduces the survival of differentiated human urinary podocyte-like epithelial cells (HUPECs), decreases intracellular glutathione (GSH) levels, and induces mitochondrial dysfunction. In a db/db mouse model of diabetes, phenyl sulfate administered at a dose of 50 mg/kg induces podocyte damage and albuminuria. Elevated plasma levels of phenyl sulfate are correlated with the progression of albuminuria in patients suffering from diabetic kidney disease, highlighting its role as a biomarker and potential therapeutic target.
Smiles
O=S(=O)(O)OC=1C=CC=CC1
Molecular Formula
C6H6O4S
Molecular Weight
174.17
Shipping Conditions
Cool pack
Storage Temperature
-20°C