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Tandutinib sulfate

CAT: 0931-T201851-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201851-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
387867-14-3
Target
Topoisomerase, Drug-Linker Conjugates for ADC, Apoptosis, Microtubule Associated, PDGFR, c-Kit
Related Pathways
Apoptosis, Antibody-drug Conjugate/ADC Related, Angiogenesis, DNA Damage/DNA Repair, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling
Bioactivity
Tandutinib (MLN518) sulfate is an effective and selective inhibitor of FLT3, with an IC50 value of 0.22 μM. It also inhibits c-Kit and PDGFR, displaying IC50 values of 0.17 μM and 0.20 μM respectively. This compound can be utilized in the treatment of acute myeloid leukemia and has the capability to cross the blood-brain barrier.
Smiles
O=C(NC1=CC=C(OC(C)C)C=C1)N2CCN(C=3N=CN=C4C=C(OCCCN5CCCCC5)C(OC)=CC43)CC2.O=S(=O)(O)O
Molecular Formula
C31H44N6O8S
Molecular Weight
660.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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