BTM-3566

CAT: 0931-T77713-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T77713-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2228857-70-1

Target

Apoptosis, Mitochondrial Metabolism

Related Pathways

Apoptosis, Metabolism

Purity

0.9995

Bioactivity

BTM-3566 activates the ISR through the mitochondrial protease OMA1.BTM-3566 induces apoptosis in cancer cells. BTM-3566 overactivates the mitochondrial ISR to study DLBCL.

Smiles

C(O)(=O)C=1N(N=C(C)C1C2=CC(F)=CC=C2)C3=NC(=C(SC(C)C)S3)C=4CCC(C(F)(F)F)CC4

Molecular Formula

C24H23F4N3O2S2

Molecular Weight

525.58

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

4-(3-Fluorophenyl)-5-methyl-2-[5-propan-2-ylsulfanyl-4-[4-(trifluoromethyl)cyclohexen-1-yl]-1,3-thiazol-2-yl]pyrazole-3-carboxylic acid

OMA1 Activator BTM-3566 is an orally bioavailable activator of the mitochondrial protease OMA1, with potential antineoplastic activity. Upon oral administration, OMA1 activator BTM-3566 activates OMA1. This leads to OMA1-dependent cleavage of DAP3-binding cell death enhancer 1 (DELE1) and mitochondrial dynamin-like GTPase OPA1, mitochondrial fragmentation, and activation of the eIF2alpha-kinase heme-regulated inhibitor (HRI), and induces cyclic AMP-dependent transcription factor ATF-4-mediated integrated stress response (ISR) and hyperactivates mitochondrial ISR, which result in apoptosis. OMA1 plays a key role in the activation of the ISR pathway in response to hypoxia, amino acid deprivation, and accumulation of misfolded proteins. While ISR promotes the adaptation of tumor cells to hypoxic stress, prolonged activation of ISR induces apoptosis.

CAS Number	2228857-70-1
PubChem CID	134564305
IUPAC Name	4-(3-fluorophenyl)-3-methyl-1-[5-propan-2-ylsulfanyl-4-[4-(trifluoromethyl)cyclohexen-1-yl]-1,3-thiazol-2-yl]pyrazole-5-carboxylic acid
Molecular Formula	C24H23F4N3O2S2
Molecular Weight	525.6
XLogP	7.3
Topological Polar Surface Area	122
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Heavy Atom Count	35
Formal Charge	0
Complexity	799

SMILES

CC1=NN(C(=C1C2=CC(=CC=C2)F)C(=O)O)C3=NC(=C(S3)SC(C)C)C4=CCC(CC4)C(F)(F)F

InChI

InChI=1S/C24H23F4N3O2S2/c1-12(2)34-22-19(14-7-9-16(10-8-14)24(26,27)28)29-23(35-22)31-20(21(32)33)18(13(3)30-31)15-5-4-6-17(25)11-15/h4-7,11-12,16H,8-10H2,1-3H3,(H,32,33)

InChIKey

LDSVVHIOWFIJNE-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2228857-70-1

CID: 134564305

Formula: C24H23F4N3O2S2

MW: 525.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	525.6
XLogP3	7.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Exact Mass	525.11678198
Monoisotopic Mass	525.11678198
Topological Polar Surface Area	122 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	799
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
BUP21463-01	BTM-3566
VAC-00787-01	BTM-P1
MBS5765839	BTM-1086
GTR19200521-01	Btm 1042
M42028	BTM - P1
BA3193-1	BTM-3528
HY-136634	BTM-1042
GTR18890611	BTM P1 peptide

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