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Jatrorrhizine hydroxide

CAT: 0931-T75436-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T75436-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
483-43-2
Target
Cholinesterase (ChE), 5-HT Receptor, Antibacterial
Related Pathways
Neuroscience, Microbiology/Virology, GPCR/G Protein
Purity
0.9999
Bioactivity
Jatrorrhizine hydroxide is an alkaloid extracted from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities. Jatrorrhizine hydroxide is a potent and orally active acetylcholinesterase inhibitor (IC50 = 872 nM) with over 115-fold selectivity over BuChE. Jatrorrhizine hydroxide reduces serotonin and norepinephrine uptake by blocking dopamine uptake-2 transporters.
Smiles
[OH-].OC=1C=C2C(=CC1OC)C=3C=C4C=CC(OC)=C(OC)C4=C[N+]3CC2
Molecular Formula
C20H21NO5
Molecular Weight
355.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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