YS-363

CAT: 0931-MF-0158178-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0158178-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2470908-90-6
Target
EGFR|||Apoptosis
Related Pathways
JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Apoptosis
Bioactivity
YS-363 is a potent, selective, and orally active inhibitor of the epidermal growth factor receptor (EGFR), with half-maximal inhibitory concentrations (IC50) of 0.96 nM for the wild-type EGFR and 0.67 nM for the L858R mutant variant. It induces G0/G1 cell cycle arrest and apoptosis in targeted cells [1].
Smiles
N=1C=NC(=C2C=C(OCCCN3CCOCC3)C(OC)=CC12)C=4C=5C=CC=CC5NC4C=6C=CC=CC6
Molecular Formula
C30H30N4O3
Molecular Weight
494.58
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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