YS-363

• Target :

  EGFR|||Apoptosis

• Related Pathways :

  JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Apoptosis

• Bioactivity :

  YS-363 is a potent, selective, and orally active inhibitor of the epidermal growth factor receptor (EGFR), with half-maximal inhibitory concentrations (IC50) of 0.96 nM for the wild-type EGFR and 0.67 nM for the L858R mutant variant. It induces G0/G1 cell cycle arrest and apoptosis in targeted cells [1].

• Smiles :

  N=1C=NC(=C2C=C(OCCCN3CCOCC3)C(OC)=CC12)C=4C=5C=CC=CC5NC4C=6C=CC=CC6

• Molecular Formula :

  C30H30N4O3

• Molecular Weight :

  494.58

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2470908-90-6