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JZP-MA-11

CAT: 0931-T75022-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T75022-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1672691-50-7
Target
Others, MAGL
Related Pathways
Others, Metabolism
Bioactivity
JZP-MA-11 is a positron emission tomography (PET) ligand that specifically targets the endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. It exhibits selective inhibition of ABHD6 with an IC50 value of 126 nM and can cross the blood-brain barrier (BBB) . The compound, labeled with [18F], shows promising potential for preclinical evaluation in mice and nonhuman primates (NHP) as a tool for investigating brain ABHD6 activity [1].
Smiles
CN(C(=O)Oc1nsnc1N1CCCCC1)c1ccc(F)cc1
Molecular Formula
C15H17FN4O2S
Molecular Weight
336.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Jzp-MA-11
CAS Number1672691-50-7
PubChem CID166642478
IUPAC Name(4-piperidin-1-yl-1,2,5-thiadiazol-3-yl) N-(4-fluorophenyl)-N-methylcarbamate
Molecular FormulaC15H17FN4O2S
Molecular Weight336.4
XLogP3.4
Topological Polar Surface Area86.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count23
Formal Charge0
Complexity403
SMILES
CN(C1=CC=C(C=C1)F)C(=O)OC2=NSN=C2N3CCCCC3
InChI
InChI=1S/C15H17FN4O2S/c1-19(12-7-5-11(16)6-8-12)15(21)22-14-13(17-23-18-14)20-9-3-2-4-10-20/h5-8H,2-4,9-10H2,1H3
InChIKey
NLWSYKNCVGFXOV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Jzp-MA-11
CAS: 1672691-50-7
CID: 166642478
Formula: C15H17FN4O2S
MW: 336.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight336.4
XLogP33.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass336.10562513
Monoisotopic Mass336.10562513
Topological Polar Surface Area86.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity403
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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