EGFR-IN-137

CAT: 0931-T203145-01Size: 10 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0931-T203145-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Target

Cytochromes P450, Apoptosis, EGFR

Related Pathways

Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis, Metabolism, Apoptosis

Bioactivity

EGFR-IN-137 (Compound 4c) acts as an inhibitor of aromatase and EGFR, with IC50 values of 1.67 μg/mL and 0.08 μg/mL, respectively. It hinders the proliferation of cancer cells MCF-7 and MDA-MB-231, with IC50 values of 1.62 μM and 4.14 μM. Additionally, EGFR-IN-137 induces cell cycle arrest at the G0/G1 phase in MDA-MB-231 cells and triggers apoptosis through a caspase-dependent pathway.

Molecular Formula

C23H21FN6O

Molecular Weight

416.45

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Related Products

Catalog	Name
T70880-01	TAK-137
T68653-01	YC-137
T87955-01	ML-137
T23777-01	BCI-137
T23010-01	MNI 137
T71875-01	OM-137
T79482-01	Anticancer agent 137
T40333	ZXH-4-137
TCL-00106-01	RM 137-15
T81577-01	P60v-src (137-157)

Alternative Products

Catalog	Name
GTR19241499-01	EGFR-IN-137
JH918720	TAK-137
MBS5811213	YC-137
BUP03803-01	MNI 137
MBS5814380	OM-137
sc-65760	AChRδ (137)
BUP07761-01	BCI-137
GTR19234261-01	ML-137
PC16866-01	CMVpp65 - 137

EGFR-IN-137

Related Products

Alternative Products

Popular Products