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PROTAC EGFR degrader 4

CAT: 0013-GTR19221170-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19221170-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC EGFR degrader 4 potently induces degradation of mutant EGFR variants, including del19 and L858R/T790M, with low nanomolar DC50 values. It demonstrates strong anti-proliferative effects in corresponding NSCLC cell lines, and its mechanism is linked to autophagy, making it a valuable tool for targeted protein degradation research in oncology.
CAS Number
2882845-50-1
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@@H] (O) CN2C (=O) [C@@H] (NC (=O) CCCCCCN2CCN (CC2) c2ccc (Nc3ncc4nc (Nc5ccccc5) n (C5CCCC5) c4n3) cc2) C (C) (C) C) cc1
Molecular Formula
C55H70N12O4S
Molecular Weight
995.29
Storage Conditions
-20°C
Notes
For research use only.

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