PSI-353661

• Target :

  Others|||HCV Protease

• Related Pathways :

  Others|||Microbiology/Virology|||Proteases/Proteasome

• Bioactivity :

  PSI-353661 (GS-558093), a purine nucleotide NS5B polymerase inhibitor, is effective against HCV infection, displaying EC90 values of 8 nM and 11 nM for wild-type and S282T resistant HCV replicons, respectively. It is capable of generating high concentrations of the active triphosphate form in primary human hepatocytes [1] [3].

• Smiles :

  COc1nc(N)nc2n(cnc12)[C@@H]1O[C@H](COP(=O)(N[C@@H](C)C(=O)OC(C)C)Oc2ccccc2)[C@@H](O)[C@@]1(C)F

• Molecular Formula :

  C24H32FN6O8P

• Molecular Weight :

  582.52

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1231747-08-2