Bcl-2-IN-5

• Target:

  Others|||Bcl-2 Family

• Related Pathways:

  Apoptosis|||Others

• Bioactivity:

  Bcl-2-IN-5 is a potent BCL-2 inhibitor with inhibitory concentrations (IC50) of 0.12 nM, 0.14 nM, and 0.22 nM against wild type Bcl-2, Bcl-2 D103Y, and Bcl-2 G101V, respectively. It also suppresses cell growth in Bcl 2-G101V knock-in [RS4;11] cells, with IC50 values of 0.2 nM and 0.44 nM.

• Smiles:

  COc1ccc (CN2CCN (C3CC4 (C3) CN (C4) c3ccc (C (=O) NS (=O) (=O) c4ccc (NC[C@H]5CC[C@] (C) (O) CC5) c (c4) N (=O) =O) c (Oc4cnc5[nH]cc (F) c5c4) c3) [C@@H] (C2) c2ccccc2C (C) C) cc1

• Molecular Formula:

  C55H63FN8O8S

• Molecular Weight:

  1015.2

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2728752-20-1