Bcl-2-IN-4

• Target:

  Bcl-2 Family|||Others

• Related Pathways:

  Others|||Apoptosis

• Bioactivity:

  Bcl-2-IN-4, an orally active and selective inhibitor of Bcl-2, demonstrates potent efficacy with an IC50 value of 1.5 nM and exhibits more than 200-fold selectivity over Bcl-xL (IC50 of 411 nM) . Additionally, it effectively inhibits the proliferation of RS4;11 cells, achieving an IC50 of 2.7 nM.

• Smiles:

  CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3cc(c(NCC4CCOCC4)c4nc[nH]c34)N(=O)=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1

• Molecular Formula:

  C46H50ClN9O7S

• Molecular Weight:

  908.46

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2703134-40-9