Imatinib Impurity E

• Target:

  Drug Metabolite|||Others

• Related Pathways:

  Others|||Metabolism

• Bioactivity:

  Imatinib Impurity E is a specific impurity found in Imatinib, an orally available inhibitor of multiple tyrosine kinases, including BCR/ABL, v-Abl, PDGFR, and c-kit. Imatinib (STI571) operates by semi-competitively inhibiting enzyme activity; it binds adjacent to the ATP binding site, inducing a closed or self-inhibited conformation [1] [2] [3] [4]. Additionally, Imatinib acts as an inhibitor against SARS-CoV and MERS-CoV [5].

• Smiles:

  N(C=1N=C(C=CN1)C=2C=CC=NC2)C3=CC(NC(=O)C4=CC=C(CN5CCN(CC6=CC=C(C(NC7=CC(NC=8N=C(C=CN8)C=9C=CC=NC9)=C(C)C=C7)=O)C=C6)CC5)C=C4)=CC=C3C

• Molecular Formula:

  C52H48N12O2

• Molecular Weight:

  873.02

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1365802-18-1