Imatinib Impurity E

CAT: 0931-T73973-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T73973-01Size:5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1365802-18-1
Target
Drug Metabolite|||Others
Related Pathways
Others|||Metabolism
Bioactivity
Imatinib Impurity E is a specific impurity found in Imatinib, an orally available inhibitor of multiple tyrosine kinases, including BCR/ABL, v-Abl, PDGFR, and c-kit. Imatinib (STI571) operates by semi-competitively inhibiting enzyme activity; it binds adjacent to the ATP binding site, inducing a closed or self-inhibited conformation [1] [2] [3] [4]. Additionally, Imatinib acts as an inhibitor against SARS-CoV and MERS-CoV [5].
Smiles
N(C=1N=C(C=CN1)C=2C=CC=NC2)C3=CC(NC(=O)C4=CC=C(CN5CCN(CC6=CC=C(C(NC7=CC(NC=8N=C(C=CN8)C=9C=CC=NC9)=C(C)C=C7)=O)C=C6)CC5)C=C4)=CC=C3C
Molecular Formula
C52H48N12O2
Molecular Weight
873.02
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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