Bosentan-d4

• CAS Number :

  1065472-77-6

• Target :

  Endothelin Receptor

• Related Pathways :

  GPCR/G Protein

• Bioactivity :

  Bosentan-d4, the deuterium-labeled variant of Bosentan, serves as a competitive dual antagonist against endothelin-1 (ET) by targeting both ET A and ET B receptors. It exhibits binding affinities with K i values of 4.7 nM for ET A and 95 nM for ET B in human SMC.

• Smiles :

  [2H]C([2H])(O)C([2H])([2H])Oc1nc(nc(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)c1Oc1ccccc1OC)-c1ncccn1

• Molecular Formula :

  C27H25D4N5O6S

• Molecular Weight :

  555.64

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C