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Bosentan-d4

CAT: 0931-T73820Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T73820Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1065472-77-6
Target
Endothelin Receptor
Related Pathways
GPCR/G Protein
Bioactivity
Bosentan-d4, the deuterium-labeled variant of Bosentan, serves as a competitive dual antagonist against endothelin-1 (ET) by targeting both ET A and ET B receptors. It exhibits binding affinities with K i values of 4.7 nM for ET A and 95 nM for ET B in human SMC.
Smiles
[2H]C([2H])(O)C([2H])([2H])Oc1nc(nc(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)c1Oc1ccccc1OC)-c1ncccn1
Molecular Formula
C27H25D4N5O6S
Molecular Weight
555.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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