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Bosentan

CAT: 0931-T6264-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T6264-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
147536-97-8
Target
Endothelin Receptor
Related Pathways
GPCR/G Protein
Purity
>99.99%
Bioactivity
Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension.
Smiles
COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCO)-c1ncccn1
Molecular Formula
C27H29N5O6S
Molecular Weight
551.614
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
B1682-100Bosentan

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