Bosentan

• Target:

  Endothelin Receptor

• Related Pathways:

  GPCR/G Protein

• Purity:

  >99.99%

• Bioactivity:

  Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension.

• Smiles:

  COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCO)-c1ncccn1

• Molecular Formula:

  C27H29N5O6S

• Molecular Weight:

  551.614

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  147536-97-8