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RO5461111

CAT: 0931-T73220-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T73220-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1252637-46-9
Target
Others, Cysteine Protease
Related Pathways
Others, Proteases/Proteasome
Bioactivity
RO5461111, a highly specific and orally active Cathepsin S antagonist, exhibits potent inhibitory effects with IC50 values of 0.4 nM (human Cathepsin S) and 0.5 nM (murine Cathepsin S), respectively. It effectively suppresses the activation of antigen-specific T cells and B cells, and can ameliorate pulmonary inflammation and lupus nephritis.
Smiles
C(=O)(C1(C(F)(F)F)CC1)N2[C@H](C(NC3(C#N)CC3)=O)C[C@@H](S(=O)(=O)C4=C(C(F)(F)F)C=C(C=C4)C=5C=C(C)N=CC5)C2
Molecular Formula
C27H24F6N4O4S
Molecular Weight
614.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
BA7226-5RO5461111

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