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RO5461111

CAT: 0804-HY-114374-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114374-01Size:5 mg
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Description
RO5461111 a highly specific and orally active antagonist of Cathepsin S with IC50s of 0.4 nM (human Cathepsin S) and 0.5 nM (murine Cathepsin S), respectively. RO5461111 can effectively inhibit the activation of antigen-specific T cells and B cells. RO5461111 can improve pulmonary inflammation and lupus nephritis[1][2].
CAS Number
1252637-46-9
Product Name Alternative
Bisdesethylchloroquine-d12, Bisdesethylchloroquine
UNSPSC
12352005
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ro5461111.html
Concentration
10mM
Purity
98.01
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(C(C2(C(F)(F)F)CC2)=O)C[C@H](S(=O)(C3=CC=C(C4=CC(C)=NC=C4)C=C3C(F)(F)F)=O)C1)NC5(C#N)CC5
Molecular Formula
C27H24F6N4O4S
Molecular Weight
614.56
References & Citations
[1]Sanchez RA, et al. Preparation of proline dipeptidyl nitrile derivatives as cathepsin, particularly cathepsin S and L, inhibitors: United States, US20100267722. 2010-10-21. |[2]Rupanagudi KV, et al. Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming. Ann Rheum Dis. 2015 Feb;74 (2) :452-63.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin S

Alternative Products

CatalogName
T73220-01RO5461111

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