EZH2-IN-14

• Target:

  Histone Methyltransferase|||Others

• Related Pathways:

  Chromatin/Epigenetic|||Others

• Bioactivity:

  EZH2-IN-14 is a selective inhibitor of EZH2 (Histone Methyltransferase) with an IC50 value of 12 nM, targeting the methyltransferase activity of EZH2/PRC2 and reducing H3K27me3 levels. It exhibits more than 200-fold selectivity for EZH2 over the closely related H3K27 methyltransferase, EZH1.

• Smiles:

  C(C)(C)N1C=2C(=C(C(NCC3=C(C)C=C(C)NC3=O)=O)C=C(C2)C=4C=CC(=NC4)N5CCN(C(C)C)CC5)C=N1

• Molecular Formula:

  C31H39N7O2

• Molecular Weight:

  541.69

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1979157-17-9